Intratumoral regional differences in DNA ploidy of gastrointestinal carcinomas
نویسندگان
چکیده
منابع مشابه
Relationship between chromosomal instability and intratumoral regional DNA ploidy heterogeneity in primary gastric cancers.
The purpose of this study was to elucidate the relationship between intratumoral regional heterogeneity in DNA ploidy and chromosomal instability (CIN) in primary gastric adenocarcinomas. In 45 sporadic gastric adenocarcinomas, we measured DNA ploidy and numerical aberrations for chromosomes 7, 11, 17, and 18 by laser scanning cytometry and fluorescence in situ hybridization, respectively, in s...
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The number of nuclear pores per sq micron was determined on the freeze-fractured nuclei of 20 human bladder tumors and five control samples of normal bladder epithelium. Measurements of the nuclear surface and volume were also performed, and the mean number of pores per nucleus and the ratio of pore to volume were calculated. The DNA distribution pattern on the same samples was determined by fl...
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To study intratumoral DNA ploidy heterogeneity and S-phase fraction (SPF) variability, we prospectively collected five different samples from 48 breast carcinomas and each sample was analysed separately by flow cytometry. Aneuploidy rate was 89.6% after analysis of four or five samples. DNA ploidy heterogeneity, i.e., different samples classified as either DNA euploid or DNA aneuploid in the sa...
متن کاملThe role of DNA ploidy and Ki-67 in the grading of mucoepidermoid carcinomas.
BACKGROUND The grading of mucoepidermoid carcinomas (MEC) is based on subjective microscopic evaluation of the prevalence of cell types as well as features of atypia and aggressiveness. Our study was aimed at evaluating the role of high-resolution DNA flow cytometry and Ki-67 expression in the grading of MEC. MATERIALS AND METHODS Fifty-five cases of intraoral and major salivary gland tumours...
متن کاملInfluence of preoperative radiotherapy on DNA ploidy in squamous cell carcinomas of the oesophagus.
The influence of preoperative radiotherapy on the prevalence of DNA aneuploidy and the prognostic significance of tumour DNA ploidy was evaluated in 126 patients with squamous cell carcinoma of the oesophagus. Preoperative radiotherapy with 30 Gy was performed in 52 patients. DNA ploidy was analysed by flow cytometry on nuclei isolated from paraffin embedded tumour tissue. DNA aneuploidy was id...
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ژورنال
عنوان ژورنال: Cancer
سال: 1988
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19881215)62:12<2569::aid-cncr2820621220>3.0.co;2-0